Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis

Glatiramer acetate (GA; Copaxone) is a random copolymer of glutamic acid, lysine, alanine, and tyrosine that is used therapeutically in patients with multiple sclerosis (MS). To investigate the mechanism of the drug’s immunomodulatory effect, we used immunophenotypic approaches to characterize the p...

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Bibliografische gegevens
Hoofdauteurs: Karandikar, Nitin J., Crawford, Michael P., Yan, Xiao, Ratts, Robert B., Brenchley, Jason M., Ambrozak, David R., Lovett-Racke, Amy E., Frohman, Elliot M., Stastny, Peter, Douek, Daniel C., Koup, Richard A., Racke, Michael K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2002
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150895/
https://ncbi.nlm.nih.gov/pubmed/11877472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14380
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