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Interleukin 13 Mutants of Enhanced Avidity Toward the Glioma-Associated Receptor, IL13Rα2
Interleukin 13 (IL13) binds a receptor that is highly overexpressed in malignant gliomas, IL13Rα2. IL13 protein is composed of four helices: α-helix A, B, C, and D, and we found a new “hot spot” in α-helix D that is crucial for the binding of IL13 to IL13Rα2. Lys-105 plus Lys-106 and Arg-109 represe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Neoplasia Press Inc.
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1508627/ https://ncbi.nlm.nih.gov/pubmed/15068667 |
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