The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

Recent evidence has defined an important role for PPARα in the transcriptional control of cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic and functional derangements of diabetic cardiomyopathy, mice with cardiac-restricted overexpression of PPARα (MHC-PPAR...

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Autori principali: Finck, Brian N., Lehman, John J., Leone, Teresa C., Welch, Michael J., Bennett, Michael J., Kovacs, Attila, Han, Xianlin, Gross, Richard W., Kozak, Ray, Lopaschuk, Gary D., Kelly, Daniel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150824/
https://ncbi.nlm.nih.gov/pubmed/11781357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14080
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