Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility

The properties of a proapoptotic 1,4-benzodiazepine, Bz-423, identified through combinatorial chemistry and phenotype screening are described. Bz-423 rapidly generated superoxide (O(2)(–)) in transformed Ramos B cells. This O(2)(–) response originated from mitochondria prior to mitochondrial transme...

Deskribapen osoa

Xehetasun bibliografikoak

Argitaratua izan da:	J Clin Invest
Egile Nagusiak:	Blatt, Neal B., Bednarski, Jeffrey J., Warner, Roscoe E., Leonetti, Francesco, Johnson, Kathryn M., Boitano, Anthony, Yung, Raymond, Richardson, Bruce C., Johnson, Kent J., Ellman, Jonathan A., Opipari, Anthony W., Glick, Gary D.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Clinical Investigation 2002
Gaiak:	Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150800/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12393848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16029
Etiketak:	Etiketa erantsi Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!