Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility

The properties of a proapoptotic 1,4-benzodiazepine, Bz-423, identified through combinatorial chemistry and phenotype screening are described. Bz-423 rapidly generated superoxide (O(2)(–)) in transformed Ramos B cells. This O(2)(–) response originated from mitochondria prior to mitochondrial transme...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Blatt, Neal B., Bednarski, Jeffrey J., Warner, Roscoe E., Leonetti, Francesco, Johnson, Kathryn M., Boitano, Anthony, Yung, Raymond, Richardson, Bruce C., Johnson, Kent J., Ellman, Jonathan A., Opipari, Anthony W., Glick, Gary D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150800/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12393848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16029
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