Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility

The properties of a proapoptotic 1,4-benzodiazepine, Bz-423, identified through combinatorial chemistry and phenotype screening are described. Bz-423 rapidly generated superoxide (O(2)(–)) in transformed Ramos B cells. This O(2)(–) response originated from mitochondria prior to mitochondrial transme...

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Номзүйн дэлгэрэнгүй

-д хэвлэсэн:	J Clin Invest
Үндсэн зохиолчид:	Blatt, Neal B., Bednarski, Jeffrey J., Warner, Roscoe E., Leonetti, Francesco, Johnson, Kathryn M., Boitano, Anthony, Yung, Raymond, Richardson, Bruce C., Johnson, Kent J., Ellman, Jonathan A., Opipari, Anthony W., Glick, Gary D.
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	American Society for Clinical Investigation 2002
Нөхцлүүд:	Article
Онлайн хандалт:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150800/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12393848/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI16029
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