Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of...

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Main Authors: Chen, Jun, Wu, Wei, Tahir, Stephen K, Kroeger, Paul E, Rosenberg, Saul H, Cowsert, Lex M, Bennett, Frank, Krajewski, Stanislaw, Krajewska, Maryla, Welsh, Kate, Reed, John C, Ng, Shi-Chung
Format: Artigo
Jezik:Inglês
Izdano: Nature America, Inc. 2000
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507573/
https://ncbi.nlm.nih.gov/pubmed/10935509
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