Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of...

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Detalhes bibliográficos
Main Authors: Chen, Jun, Wu, Wei, Tahir, Stephen K, Kroeger, Paul E, Rosenberg, Saul H, Cowsert, Lex M, Bennett, Frank, Krajewski, Stanislaw, Krajewska, Maryla, Welsh, Kate, Reed, John C, Ng, Shi-Chung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature America, Inc. 2000
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507573/
https://ncbi.nlm.nih.gov/pubmed/10935509
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