Down-regulation of Survivin by Antisense Oligonucleotides Increases Apoptosis, Inhibits Cytokinesis and Anchorage-Independent Growth

Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of...

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Autors principals: Chen, Jun, Wu, Wei, Tahir, Stephen K, Kroeger, Paul E, Rosenberg, Saul H, Cowsert, Lex M, Bennett, Frank, Krajewski, Stanislaw, Krajewska, Maryla, Welsh, Kate, Reed, John C, Ng, Shi-Chung
Format: Artigo
Idioma:Inglês
Publicat: Nature America, Inc. 2000
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1507573/
https://ncbi.nlm.nih.gov/pubmed/10935509
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