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p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative substrate of the ataxia telangiectasia-mutated (ATM) kinase. To study the biological role of 53BP1, we di...

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Udgivet i:Mol Cell Biol
Principais autores: Ward, Irene M., Minn, Kay, van Deursen, Jan, Chen, Junjie
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150747/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12640136/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.7.2556-2563.2003
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