The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERK-Mediated Actin Spike Formation: Deregulation in Cancer Cells

Integrins play an important role in tumour progression by influencing cellular responses and matrix-dependent adhesion. However, the regulation of matrix-dependent adhesion assembly in epithelial cells is poorly understood. We have investigated the integrin and signalling requirements of cell-matrix...

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Detalhes bibliográficos
Main Authors: Brunton, Valerie G, Fincham, Valerie J, McLean, Gordon W, Winder, Steven J, Paraskeva, Christos, Marshall, John F, Frame, Margaret C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1505596/
https://ncbi.nlm.nih.gov/pubmed/11494115
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