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Src SH3/2 Domain-mediated Peripheral Accumulation of Src and Phospho-myosin Is Linked to Deregulation of E-cadherin and the Epithelial-Mesenchymal Transition

Elevated Src kinase in epithelial cancer cells induces adhesion changes that are associated with a mesenchymal-like state. We recently showed that Src induces dynamic integrin adhesions in KM12C colon cancer cells, whereas E-cadherin–dependent cell-cell contacts become disorganized. This promotes a...

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Detalhes bibliográficos
Main Authors: Avizienyte, Egle, Fincham, Valerie J., Brunton, Valerie G., Frame, Margaret C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC420103/
https://ncbi.nlm.nih.gov/pubmed/15075377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0879
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