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Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold Protein

Ste5 is essential for pheromone response and binds components of a mitogen-activated protein kinase (MAPK) cascade: Ste11 (MEKK), Ste7 (MEK), and Fus3 (MAPK). Pheromone stimulation releases Gβγ (Ste4-Ste18), which recruits Ste5 and Ste20 (p21-activated kinase) to the plasma membrane, activating the...

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Detalhes bibliográficos
Main Authors: Sette, Claudio, Inouye, Carla J., Stroschein, Shannon L., Iaquinta, Phillip J., Thorner, Jeremy
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15055/
https://ncbi.nlm.nih.gov/pubmed/11071925
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