Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold Protein

Ste5 is essential for pheromone response and binds components of a mitogen-activated protein kinase (MAPK) cascade: Ste11 (MEKK), Ste7 (MEK), and Fus3 (MAPK). Pheromone stimulation releases Gβγ (Ste4-Ste18), which recruits Ste5 and Ste20 (p21-activated kinase) to the plasma membrane, activating the...

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Опубликовано в::	Mol Biol Cell
Главные авторы:	Sette, Claudio, Inouye, Carla J., Stroschein, Shannon L., Iaquinta, Phillip J., Thorner, Jeremy
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Cell Biology 2000
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15055/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11071925/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.11.4033
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