Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins

This study evaluates the use of vectors based on adeno-associated viruses (AAVs) to noninvasively deliver genes to airway epithelial cells as a means for achieving systemic administration of therapeutic proteins. We intranasally delivered AAV vectors to mice in which the same AAV2 genome encoding a...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Auricchio, Alberto, O’Connor, Erin, Weiner, Daniel, Gao, Guang-Ping, Hildinger, Markus, Wang, Lili, Calcedo, Roberto, Wilson, James M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150421/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189244/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15780
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