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Cyclooxygenase-1–selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus

Preterm delivery is the leading cause of neonatal mortality and contributes significantly to infant morbidity. Classical cyclooxygenase (COX) inhibitors, such as indomethacin, which inhibit both COX-1 and COX-2, are effective for delaying premature labor, but their use is limited by serious complica...

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Detalhes bibliográficos
Main Authors: Loftin, Charles D., Trivedi, Darshini B., Langenbach, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC150416/
https://ncbi.nlm.nih.gov/pubmed/12189249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14924
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