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Inhibition of cyclooxygenase isoforms in late- but not midgestation decreases contractility of the ductus arteriosus and prevents postnatal closure in mice

Use of cyclooxygenase (COX) inhibitors to delay preterm birth is complicated by in utero constriction of the ductus arteriosus and delayed postnatal closure. Delayed postnatal closure has been attributed to loss of vasa vasorum flow and ductus wall ischemia resulting from constriction in utero. We u...

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Detalhes bibliográficos
Main Authors: Reese, Jeff, Anderson, Judy D., Brown, Naoko, Roman, Christine, Clyman, Ronald I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2819844/
https://ncbi.nlm.nih.gov/pubmed/16857891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00259.2006
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