Chronic in utero cyclooxygenase inhibition alters PGE2-regulated ductus arteriosus contractile pathways and prevents postnatal closure

Although prostaglandin E2 (PGE2) vasodilates the ductus arteriosus, tocolysis with cyclooxygenase (COX) inhibitors delays postnatal ductus arteriosus closure. We used fetal mice and sheep to determine if PGE2 has a role in the development of ductus contractility that is distinct from its function as...

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Hauptverfasser: Reese, Jeff, Waleh, Nahid, Poole, Stanley D., Brown, Naoko, Roman, Christine, Clyman, Ronald I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066019/
https://ncbi.nlm.nih.gov/pubmed/19390487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1203/PDR.0b013e3181aa07eb
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