A Point Mutation in the Transmembrane Domain of the Hemagglutinin of Influenza Virus Stabilizes a Hemifusion Intermediate That Can Transit to Fusion

A hemagglutinin (HA) of influenza virus having a single semiconserved Gly residue within the transmembrane domain mutated to Leu (G520L) was expressed on cells; these cells were bound to red blood cells. By decreasing pH at 23°C rather than 37°C, an intermediate with properties expected of hemifusio...

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Veröffentlicht in:	Mol Biol Cell
Hauptverfasser:	Melikyan, Grigory B., Markosyan, Ruben M., Roth, Michael G., Cohen, Fredric S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Cell Biology 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11071905/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.11.3765
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