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A Point Mutation in the Transmembrane Domain of the Hemagglutinin of Influenza Virus Stabilizes a Hemifusion Intermediate That Can Transit to Fusion

A hemagglutinin (HA) of influenza virus having a single semiconserved Gly residue within the transmembrane domain mutated to Leu (G520L) was expressed on cells; these cells were bound to red blood cells. By decreasing pH at 23°C rather than 37°C, an intermediate with properties expected of hemifusio...

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Autors principals: Melikyan, Grigory B., Markosyan, Ruben M., Roth, Michael G., Cohen, Fredric S.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC15035/
https://ncbi.nlm.nih.gov/pubmed/11071905
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