Mutant K-ras Regulates Cathepsin B Localization on the Surface of Human Colorectal Carcinoma Cells

Cathepsin B protein and activity are known to localize to the basal plasma membrane of colon carcinoma cells following the appearance of K-ras mutations. Using immunofluorescence and subcellular fractionation techniques and two human colon carcinoma cell lines—one with a mutated K-ras allele (HCT 11...

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Hauptverfasser: Cavallo-Medved, Dora, Dosescu, Julie, Linebaugh, Bruce E., Sameni, Mansoureh, Rudy, Debbie, Sloane, Bonnie F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press Inc. 2003
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502576/
https://ncbi.nlm.nih.gov/pubmed/14965444
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