Bone Microenvironment Modulates Expression and Activity of Cathepsin B in Prostate Cancer

Prostate cancers metastasize to bone leading to osteolysis. Here we assessed proteolysis of DQ-collagen I (a bone matrix protein) and, for comparison, DQ-collagen IV, by living human prostate carcinoma cells in vitro. Both collagens were degraded, and this degradation was reduced by inhibitors of ma...

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Main Authors: Podgorski, Izabela, Linebaugh, Bruce E, Sameni, Mansoureh, Jedeszko, Christopher, Bhagat, Sunita, Cher, Michael L, Sloane, Bonnie F
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press Inc. 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1501133/
https://ncbi.nlm.nih.gov/pubmed/15799821
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