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A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor β
Evidence is presented that the estrogen antagonist 4-hydroxytamoxifen (HT) can occupy not only the core binding pocket within the ligand-binding domain of estrogen receptor (ER) β but also a second site on its surface. The crystal structure of the ligand-binding domain (LBD) associated with HT was d...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502552/ https://ncbi.nlm.nih.gov/pubmed/16782818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510596103 |
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