A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor β

Evidence is presented that the estrogen antagonist 4-hydroxytamoxifen (HT) can occupy not only the core binding pocket within the ligand-binding domain of estrogen receptor (ER) β but also a second site on its surface. The crystal structure of the ligand-binding domain (LBD) associated with HT was d...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Yong, Chirgadze, Nickolay Y., Briggs, Stephen L., Khan, Sohaib, Jensen, Elwood V., Burris, Thomas P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502552/
https://ncbi.nlm.nih.gov/pubmed/16782818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510596103
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