Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells

Golgi α-mannosidase II, a key enzyme in N-glycan processing, is a target in the development of anti- cancer therapies. The crystal structure of Drosophila Golgi α-mannosidase II in the absence and presence of the anti-cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel pro...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	van den Elsen, Jean M.H., Kuntz, Douglas A., Rose, David R.
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2001
Assuntos:	Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150216/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11406577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.12.3008
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