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Structure of Golgi α-mannosidase II: a target for inhibition of growth and metastasis of cancer cells
Golgi α-mannosidase II, a key enzyme in N-glycan processing, is a target in the development of anti- cancer therapies. The crystal structure of Drosophila Golgi α-mannosidase II in the absence and presence of the anti-cancer agent swainsonine and the inhibitor deoxymannojirimycin reveals a novel pro...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150216/ https://ncbi.nlm.nih.gov/pubmed/11406577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.12.3008 |
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