MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

BACKGROUND: The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important...

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Detalhes bibliográficos
Main Authors: Pikman, Yana, Lee, Benjamin H, Mercher, Thomas, McDowell, Elizabeth, Ebert, Benjamin L, Gozo, Maricel, Cuker, Adam, Wernig, Gerlinde, Moore, Sandra, Galinsky, Ilene, DeAngelo, Daniel J, Clark, Jennifer J, Lee, Stephanie J, Golub, Todd R, Wadleigh, Martha, Gilliland, D. Gary, Levine, Ross L
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502153/
https://ncbi.nlm.nih.gov/pubmed/16834459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0030270
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