A Sensitive Detection Method for MPLW515L or MPLW515K Mutation in Chronic Myeloproliferative Disorders with Locked Nucleic Acid-Modified Probes and Real-Time Polymerase Chain Reaction

Acquired mutations in the juxtamembrane region of MPL (W515K or W515L), the receptor for thrombopoietin, have been described in patients with primary myelofibrosis or essential thrombocythemia, which are chronic myeloproliferative disorders. We have developed a real-time polymerase chain reaction as...

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Main Authors: Pancrazzi, Alessandro, Guglielmelli, Paola, Ponziani, Vanessa, Bergamaschi, Gaetano, Bosi, Alberto, Barosi, Giovanni, Vannucchi, Alessandro M.
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2008
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Regular Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518738/
https://ncbi.nlm.nih.gov/pubmed/18669880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/jmoldx.2008.080015
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