Glutathione Depletion Induced by c-Myc Downregulation Triggers Apoptosis on Treatment with Alkylating Agents

Here we investigate the mechanism(s) involved in the c-Myc-dependent drug response of melanoma cells. By using three M14-derived c-Myc low-expressing clones, we demonstrate that alkylating agents, cisplatin and melphalan, trigger apoptosis in the c-Myc antisense transfectants, but not in the parenta...

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Bibliografiska uppgifter
Huvudupphovsmän: Biroccio, Annamaria, Benassi, Barbara, Fiorentino, Francesco, Zupi, Gabriella
Materialtyp: Artigo
Språk:Inglês
Publicerad: Neoplasia Press Inc. 2004
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502103/
https://ncbi.nlm.nih.gov/pubmed/15153331
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