A Novel Method for Imaging Apoptosis Using a Caspase-1 Near-Infrared Fluorescent Probe

Here we describe a novel method for imaging apoptosis in cells using a near-infrared fluorescent (NIRF) probe selective for caspase-1 (interleukin 1β-converting enzyme, ICE). This biocompatible, optically quenched ICE-NIRF probe incorporates a peptide substrate, which can be selectively cleaved by c...

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Main Authors: Messerli, Shanta M, Prabhakar, Shilpa, Tang, Yi, Shah, Khalid, Cortes, Maria L, Murthy, Vidya, Weissleder, Ralph, Breakefield, Xandra O, Tung, Ching-Hsuan
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502090/
https://ncbi.nlm.nih.gov/pubmed/15140398
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