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Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP
XIAP is a mammalian inhibitor of apoptosis protein (IAP). To determine residues within the second baculoviral IAP repeat (BIR2) required for inhibition of caspase 3, we screened a library of BIR2 mutants for loss of the ability to inhibit caspase 3 toxicity in the yeast Schizosaccharomyces pombe. Fo...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150202/ https://ncbi.nlm.nih.gov/pubmed/11406588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.12.3114 |
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