Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a common theme in human malignancies. We have devel...

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Autori principali: Shi, Yan, Liu, Xuesong, Han, Edward K., Guan, Ran, Shoemaker, Alexander R., Oleksijew, Anatol, Woods, Keith W., Fisher, John P., Klinghofer, Vered, Lasko, Loren, McGonigal, Thomas, Li, Qun, Rosenberg, Saul H., Giranda, Vincent L., Luo, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press, Inc. 2005
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502019/
https://ncbi.nlm.nih.gov/pubmed/16331885
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