Akt Inhibitor A-443654 Interferes with Mitotic Progression by Regulating Aurora A Kinase Expression

Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. We report here that Compound A (A-443654), a specific Akt inhibitor, interferes with mitotic progression and bipolar spindle formation. Compound A induces G(2)/M accumulation, defects in centros...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Xuesong, Shi, Yan, Woods, Keith W, Hessler, Paul, Kroeger, Paul, Wilsbacher, Julie, Wang, Jieyi, Wang, Jean Y, Li, Chunying, Li, Qun, Rosenberg, Saul H, Giranda, Vincent L, Luo, Yan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Neoplasia Press Inc. 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481570/
https://ncbi.nlm.nih.gov/pubmed/18670641
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