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Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo
Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a common theme in human malignancies. We have devel...
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Main Authors: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Neoplasia Press, Inc.
2005
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1502019/ https://ncbi.nlm.nih.gov/pubmed/16331885 |
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