Antigenic Hepatitis A Virus Structures May Be Produced in Escherichia coli

The synthesis of 14S pentamers and 70S empty capsids of hepatitis A virus (HAV) has been accomplished by expressing the viral genome for periods of time longer than 4 h in Escherichia coli. HAV pentamers (14S) self-assembled into capsids (70S) in vitro. The antibodies induced by these structures rec...

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Bibliographic Details
Main Authors: Sánchez, Glòria, Caballero, Santiago, Guix, Susana, Bosch, Albert, Pintó, Rosa M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Physiology and Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC150110/
https://ncbi.nlm.nih.gov/pubmed/12620879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.3.1840-1843.2003
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