Cytoplasmic expression systems triggered by mRNA yield increased gene expression in post-mitotic neurons

Non-viral vectors are promising vehicles for gene therapy but delivery of plasmid DNA to post-mitotic cells is challenging as nuclear entry is particularly inefficient. We have developed and evaluated a hybrid mRNA/DNA system designed to bypass the nuclear barrier to transfection and facilitate cyto...

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Autors principals: Farrow, Paul J., Barrett, Lee B., Stevenson, Mark, Fisher, Kerry D., Finn, Jonathan, Spice, Rachel, Allan, Michael A., Berry, Martin, Logan, Ann, Seymour, Leonard W., Read, Martin L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2006
Matèries:
Methods Online
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500874/
https://ncbi.nlm.nih.gov/pubmed/16835307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl442
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