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Structural insights into substrate traffic and inhibition in acetylcholinesterase

Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. Substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which have been suggested to be allosterica...

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書誌詳細
主要な著者: Colletier, Jacques-Philippe, Fournier, Didier, Greenblatt, Harry M, Stojan, Jure, Sussman, Joel L, Zaccai, Giuseppe, Silman, Israel, Weik, Martin
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500847/
https://ncbi.nlm.nih.gov/pubmed/16763558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601175
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