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Structural insights into substrate traffic and inhibition in acetylcholinesterase
Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. Substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which have been suggested to be allosterica...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1500847/ https://ncbi.nlm.nih.gov/pubmed/16763558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601175 |
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