Structural insights into substrate traffic and inhibition in acetylcholinesterase

Acetylcholinesterase (AChE) terminates nerve-impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine. Substrate traffic in AChE involves at least two binding sites, the catalytic and peripheral anionic sites, which have been suggested to be allosterica...

Full description

Saved in:
Bibliographic Details
Main Authors: Colletier, Jacques-Philippe, Fournier, Didier, Greenblatt, Harry M, Stojan, Jure, Sussman, Joel L, Zaccai, Giuseppe, Silman, Israel, Weik, Martin
Format: Artigo
Language:Inglês
Published: 2006
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1500847/
https://ncbi.nlm.nih.gov/pubmed/16763558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601175
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items