An α-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain

The water channel AQP4 is concentrated in perivascular and subpial membrane domains of brain astrocytes. These membranes form the interface between the neuropil and extracerebral liquid spaces. AQP4 is anchored at these membranes by its carboxyl terminus to α-syntrophin, an adapter protein associate...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Amiry-Moghaddam, Mahmood, Otsuka, Takashi, Hurn, Patricia D., Traystman, Richard J., Haug, Finn-Mogens, Froehner, Stanley C., Adams, Marvin E., Neely, John D., Agre, Peter, Ottersen, Ole Petter, Bhardwaj, Anish
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149966/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12578959/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0437946100
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