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Tissue transglutaminase-induced aggregation of α-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies

Proteinaceous aggregates containing α-synuclein represent a feature of neurodegenerative disorders such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Despite extensive research, the mechanisms underlying α-synuclein aggregation remain elusive. Previously, tissu...

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Main Authors: Junn, Eunsung, Ronchetti, Ruben D., Quezado, Martha M., Kim, Soo-Youl, Mouradian, M. Maral
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2003
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC149956/
https://ncbi.nlm.nih.gov/pubmed/12576551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0438021100
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