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Molecular bases of defective signal transduction in the platelet P2Y(12) receptor of a patient with congenital bleeding
We have identified structural attributes required for signal transduction through a seven-transmembrane-domain receptor. Platelets from a patient (AC) with a congenital bleeding disorder had normal shape change but reduced and reversible aggregation in response to 4 μM ADP, similar to normal platele...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149944/ https://ncbi.nlm.nih.gov/pubmed/12578987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437879100 |
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