Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection

No transgenic cystic fibrosis (CF) mouse model developed to date mimics the major clinical phenotype found in humans with CF, chronic Pseudomonas aeruginosa lung infection. In a transgenic CF transmembrane conductance regulator (cftr) mouse colony, we found WT, heterozygous, and homozygous CF mice h...

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Autors principals: Coleman, Fadie T., Mueschenborn, Simone, Meluleni, Gloria, Ray, Christopher, Carey, Vincent J., Vargas, Sara O., Cannon, Carolyn L., Ausubel, Frederick M., Pier, Gerald B.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC149939/
https://ncbi.nlm.nih.gov/pubmed/12578988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437901100
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