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Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection

No transgenic cystic fibrosis (CF) mouse model developed to date mimics the major clinical phenotype found in humans with CF, chronic Pseudomonas aeruginosa lung infection. In a transgenic CF transmembrane conductance regulator (cftr) mouse colony, we found WT, heterozygous, and homozygous CF mice h...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Coleman, Fadie T., Mueschenborn, Simone, Meluleni, Gloria, Ray, Christopher, Carey, Vincent J., Vargas, Sara O., Cannon, Carolyn L., Ausubel, Frederick M., Pier, Gerald B.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149939/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12578988/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0437901100
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