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Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

There is a concern that increased paternal age may be associated with altered fertility and an increased incidence of birth defects in man. In previous studies of aged male rats, we have found abnormalities in the fertility and in the embryos sired by older males. Aging in mammals is associated with...

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Auteurs principaux: Oakes, Christopher C., Smiraglia, Dominic J., Plass, Christoph, Trasler, Jacquetta M., Robaire, Bernard
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 2003
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC149909/
https://ncbi.nlm.nih.gov/pubmed/12574505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437971100
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