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Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding

BACKGROUND: The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean f...

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Detalhes bibliográficos
Main Authors: Wilke, Claus O, Lenski, Richard E, Adami, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149451/
https://ncbi.nlm.nih.gov/pubmed/12590655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-3-3
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