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Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation

Picornavirus proteases cleave translation initiation factor eIF4G into a C-terminal two-thirds fragment (hereafter named p100) and an N-terminal one-third fragment, which interacts with the cap-binding factor eIF4E. As the timing of this cleavage correlates broadly with the shut-off of host cell pro...

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Udgivet i:EMBO J
Principais autores: Ali, Iraj K., McKendrick, Linda, Morley, Simon J., Jackson, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149147/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483526/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.15.4233
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