Activation and Deactivation of a Broad-Spectrum Antiviral Drug by a Single Enzyme: Adenosine Deaminase Catalyzes Two Consecutive Deamination Reactions

Ribavirin is an approved broad-spectrum antiviral drug. A liver-targeting prodrug of ribavirin, viramidine, is in clinical trial in an attempt to provide a better therapeutic index. The conversion of viramidine to ribavirin, and of ribavirin to an inactive metabolite through adenosine deaminase, is...

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Bibliographic Details
Main Authors: Wu, Jim Zhen, Walker, Heli, Lau, Johnson Y. N., Hong, Zhi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC149024/
https://ncbi.nlm.nih.gov/pubmed/12499231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.426-431.2003
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