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A Phe389Leu Substitution in ErgA Confers Terbinafine Resistance in Aspergillus fumigatus
Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution th...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1489775/ https://ncbi.nlm.nih.gov/pubmed/16801438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00187-06 |
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