Interaction of Antimicrobial Peptide Temporin L with Lipopolysaccharide In Vitro and in Experimental Rat Models of Septic Shock Caused by Gram-Negative Bacteria

Sepsis remains a major cause of morbidity and mortality in hospitalized patients, despite intense efforts to improve survival. The primary lead for septic shock results from activation of host effector cells by endotoxin, the lipopolysaccharide (LPS) associated with cell membranes of gram-negative b...

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Bibliographic Details
Main Authors: Giacometti, Andrea, Cirioni, Oscar, Ghiselli, Roberto, Mocchegiani, Federico, Orlando, Fiorenza, Silvestri, Carmela, Bozzi, Argante, Di Giulio, Antonio, Luzi, Carla, Mangoni, Maria Luisa, Barra, Donatella, Saba, Vittorio, Scalise, Giorgio, Rinaldi, Andrea C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489763/
https://ncbi.nlm.nih.gov/pubmed/16801429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01553-05
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