Isolation, Characterization, and Heterologous Expression of the Biosynthesis Gene Cluster for the Antitumor Anthracycline Steffimycin

The biosynthetic gene cluster for the aromatic polyketide steffimycin of the anthracycline family has been cloned and characterized from “Streptomyces steffisburgensis” NRRL 3193. Sequence analysis of a 42.8-kbp DNA region revealed the presence of 36 open reading frames (ORFs) (one of them incomplet...

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Autores principales: Gullón, Sonia, Olano, Carlos, Abdelfattah, Mohamed S., Braña, Alfredo F., Rohr, Jürgen, Méndez, Carmen, Salas, José A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Physiology and Biotechnology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489666/
https://ncbi.nlm.nih.gov/pubmed/16751529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00734-06
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