Contributions of Antibiotic Penetration, Oxygen Limitation, and Low Metabolic Activity to Tolerance of Pseudomonas aeruginosa Biofilms to Ciprofloxacin and Tobramycin

The roles of slow antibiotic penetration, oxygen limitation, and low metabolic activity in the tolerance of Pseudomonas aeruginosa in biofilms to killing by antibiotics were investigated in vitro. Tobramycin and ciprofloxacin penetrated biofilms but failed to effectively kill the bacteria. Bacteria...

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Detalhes bibliográficos
Main Authors: Walters, Marshall C., Roe, Frank, Bugnicourt, Amandine, Franklin, Michael J., Stewart, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC148957/
https://ncbi.nlm.nih.gov/pubmed/12499208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.1.317-323.2003
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